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|
Gene : |
KLRB1 |
Gene ID : |
3820 |
Uniprot ID : |
Q12918 |
Alternative Name : |
KLRB1, CLEC5B, NKRP1A |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
ABM2D74 |
Isotype : |
Mouse IgG1 Kappa |
Immunogen Information : |
A full length human CD161 protein was used as the immunogen for this antibody. |
CD161 is the human equivalent of mouse NK cell receptor P1A. It is a type II transmembrane glycoprotein with characteristics of the C-type lectin superfamily. The expression confines to lymphocytes found in human gut and liver, as well as blood, especially NK (natural killer) cells, Th17 (T helper 17) cells, and a population of unconventional T cells known as MAIT (mucosal-associated invariant T) cells. CD161 promotes T cell expansion and eventually has been identified as a marker of human IL-17-producing T cells. It plays a pivotal role in trans-endothelial migration and is also implicated in the pathogenesis of RA (rheumatoid arthritis) as well as graft-versus-host disease (GVHD).
Western blot analysis: 2-4 µg/ml,
Immunohistochemical analysis: 5 µg/ml
FACS: 0.2-0.5 µg/10^6 cells