sdMAB â„¢ (Single Domain Monoclonal Antibody)

A single domain monoclonal antibody (sdAb) is a type of antibody derived from camelids, such as camels, llamas or Alpacas (VHH) and Shark (VNAR). It is also called VHH (variable domain of heavy chain of HCAb) or VNAR (Variable domain of new antigen receptor) due to its small size compared to conventional antibodies. 

 

Unlike conventional antibodies, which are composed of two heavy chains and two light chains, sdAbs consist of a single, fully functional antibody domain. This single domain contains both the antigen-binding site and the effector functions necessary for immune response. They have gained significant importance in various fields of research and technology due to their distinctive structure, functional properties, and advantages over conventional antibodies.