Monoclonal antibody to Hid-5/S100A7/Psoriasin (Clone: ABM18A5)

Product code: 10-10003

Clonality : Monoclonal
Application : FACS, WB
Reactivity : Human

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2000 throughout India Order now and get it on next 3-4 working days (Major Cities)

Gene : S100A7
Gene ID : 6278
Uniprot ID : P31151
Alternative Name : S100A7, PSOR1, S100A7C
Format : Purified
Amount : 100 µg
Clone name : ABM18A5
Isotype : Mouse IgG1 Kappa
Immunogen Information : A partial length recombinant human psoriasin/HID-5 protein was used as the immunogen for this antibody.

Psoriasin (S100A7) is a protein of low molecular weight that belongs to the S100 protein family, which are EF-hand calcium-binding proteins. Originally identified in psoriasis, Psoriasin functions as a transglutaminase substrate/cornified envelope precursor, signal transduction protein, chemokine, and antibacterial protein in normal epidermis. Psoriasin is upregulated in primary keratinocytes and is a major player in the local innate defense of healthy skin against bacteria. Furthermore, it plays a role in wound healing, a pathophysiological process associated with inflammation and involving its release by keratinocytes into wound fluid. It has been found to kill by sequestering trace elements, such as zinc, and by directly permeabilizing bacterial cell membranes. In the intracellular compartment, S100A7 appears to interact with epidermal fatty acid-binding protein (E-FABP). S100A7 is also found in the extracellular environment. It is reported to be found in psoriatic plaque exudate, as is its binding partner E-FABP. In addition, S100A7 may be released from cultured keratinocytes, and it may act as a chemotactic agent, a function that has been reported for S100A7 in non-epidermal tissues. Psoriasin is over-expressed in abnormal conditions like epidermal hyperproliferative disorders, which share the following features: cellular and vascular hyperproliferation, abnormal differentiation and lymphocytic infiltration. In high-grade ductal carcinoma in situ, Psoriasin was identified as one of the most abundant transcripts. Psoriasin is induced by reactive oxygen species (ROS) and the downregulation of psoriasin by short hairpin RNA (shRNA) leads to reduced expression of vascular endothelial growth factor (VEGF) and inhibits tumor growth in vivo.  Psoriasin may also play a role in breast cancer progression by promoting oxidative stress response and angiogenesis.

Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Western blot analysis:2-4 µg/ml;FACS Analysis: 0.5-1 µg/10^6 cells


Monoclonal antibody to Hid-5/S100A7/Psoriasin (Clone: ABM18A5)

Product code: 10-10003
mg

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