Polyclonal Antibody to Beta actin

Product code: 11-13012

Clonality : Polyclonal
Application : WB
Reactivity : Rat, Mouse, Human

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Gene : ACTB
Gene ID : 60
Uniprot ID : P60709
Alternative Name : Actin, cytoplasmic 1, ACTB
Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Immunogen Information : A partial length recombinant Beta actin protein (amino acids 1-200) was used as the immunogen for this antibody.

Beta actin (ACTB) has traditionally been regarded as an endogenous housekeeping gene and has been widely used as a reference gene/protein in quantifying expression levels in tumors. It supports fundamental cellular processes in healthy and diseased cells including cell adhesion, migration, cytokinesis and maintenance of cell polarity. However, Beta actin is closely associated with a variety of cancers and accumulating evidence indicates that Beta actin is de-regulated in liver, melanoma, renal, colorectal, gastric, pancreatic, esophageal, lung, breast, prostate, ovarian cancers, leukemia and lymphoma. This protein is generally found to be up-regulated in the majority of tumor cells and tissues.

Purification : Protein A Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Western blot analysis: 4-6 µg/ml:

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2. Nayak TK, Mamidi P, Kumar A, Singh LP, Sahoo SS, Chattopadhyay S, Chattopadhyay S. Regulation of Viral Replication, Apoptosis and Pro-Inflammatory Responses by 17-AAG during Chikungunya Virus Infection in Macrophages. Viruses. 2017 Jan 6;9(1). pii: E3. doi: 10.3390/v9010003. PubMed PMID: 28067803; PubMed Central PMCID: PMC5294972.

3. Panigrahi B, Singh RK, Mishra S, Mandal D. Cyclic peptide-based nanostructures as efficient siRNA carriers. Artif Cells Nanomed Biotechnol. 2018 Oct 12:1-11. doi: 10.1080/21691401.2018.1511574. [Epub ahead of print] PubMed PMID: 30311806.

4. Panigrahi B, Mishra S, Singh RK, Siddiqui N, Bal R, Mandal D. Peptide generated anisotropic gold nanoparticles as efficient siRNA vectors. Int J Pharm. 2019 May 30;563:198-207. doi: 10.1016/j.ijpharm.2019.04.007. Epub 2019 Apr 3. PubMed PMID: 30953762.

5. Yavvari PS, Verma P, Mustfa SA, Pal S, Kumar S, Awasthi AK, Ahuja V, Srikanth CV, Srivastava A, Bajaj A. A nanogel based oral gene delivery system targeting SUMOylation machinery to combat gut inflammation. Nanoscale. 2019 Mar 14;11(11):4970-4986. doi: 10.1039/c8nr09599j. PubMed PMID: 30839018.

6. Shahror RA, Linares G, Wang Y, Hsueh SC, Wu CC, Chuang DM, Chiang YH, Chen KY. Transplantation of Mesenchymal Stem Cells Overexpressing FGF21 Facilitates Cognitive Recovery and Enhances Neurogenesis in a Mouse Model of Traumatic Brain Injury. J Neurotrauma. 2019 Jul 12. doi: 10.1089/neu.2019.6422. [Epub ahead of print] PubMed PMID: 31298621.

Polyclonal Antibody to Beta actin

Product code: 11-13012

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