|
|
| Gene : |
CASP3 |
| Gene ID : |
836 |
| Uniprot ID : |
P42574 |
| Alternative Name : |
Casp3, Cpp32 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM1C12 |
| Isotype : |
Mouse IgG1 Kappa |
| Immunogen Information : |
Full length recombinant Caspase-3 protein was used as the immunogen for this antibody. |
Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death. Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis.
Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5-10 µg/ml, FACS analysis: 0.5-1 µg/10^6 cells
