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|
| Gene : |
CD274 |
| Gene ID : |
29126 |
| Uniprot ID : |
Q9NZQ7 |
| Alternative Name : |
CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM5F25 |
| Isotype : |
Mouse IgG2b Kappa |
| Immunogen Information : |
A partial length recombinant protein of PD-L1 (amino acid 13-224) was used as the immunogen for this antibody. |
PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.
FACS analysis: 0.5-1 µg/10^6 cells; Western blot analysis: 2-4 µg/ml; Immunohistochemical analysis: 5-10 µg/ml
