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|
| Gene : |
EPCAM |
| Gene ID : |
4072 |
| Uniprot ID : |
P16422 |
| Alternative Name : |
Epithelial cell adhesion molecule, Ep-CAM,
Adenocarcinoma-associated antigen, Cell surface glycoprotein Trop-1, Epithelial
cell surface antigen, Epithelial glycoprotein, EGP, Epithelial glycoprotein
314, EGP314, hEGP314, KS 1/4 antigen, KSA, Major ga |
| Format : |
Purified |
| Amount : |
20 µg |
| Clone name : |
PAT37F9AT |
| Isotype : |
Mouse IgG1 heavy chain and k light chain. |
| Immunogen Information : |
Anti-human EPCAM mAb,
clone PAT37F9AT, is derived from hybridization of mouse F0 myeloma cells with
spleen cells from BALB/c mice immunized with a recombinant human EPCAM protein 24-265
amino acids purified from E. coli. |
EPCAM is a carcinoma-associated antigen and belongs to a family which includes at least 2 type I membrane proteins. The EPCAM protein has a role in embryonic stem cells proliferation and differentiation. EPCAM is used as a target for immunotherapy treatment of human carcinomas. EPCAM is expressed on most normal epithelial cells and gastrointestinal carcinomas and acts as a homotypic calcium-independent cell adhesion molecule. Epithelial cell adhesion molecules (EPCAM) can act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for supplying immunological barrier as a first line of defense against mucosal infection. EPCAM gene mutations result in congenital tufting enteropathy.
The antibody has been tested by ELISA, Western blot
analysis to assure specificity and reactivity. Since application varies,
however, each investigation should be titrated by the reagent to obtain optimal
results. Recommended starting dilution is 1:500.
