Recombinant anti-human-IL-1β Antibody (Canakinumab)

Product code: 10-2003

Clonality : Monoclonal
Application : Functional Assay, IP, ELISA, ICC/IF, IHC, FACS
Reactivity : Human

Shipping Info:

Availability 5-7 weeks.

Size
Price
100 μg


Shipping Info:

Availability 5-7 weeks.

Gene : IL1B
Gene ID : 3553
Uniprot ID : P01584
Alternative Name : Interleukin-1 beta, Catabolin
Format : Purified
Amount : 100 μg

Target: IL-1 Beta
Generic name: Canakinumab
Product Origin: Recombinant in CHO cells

Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass with a molecular mass of 145157 Daltons when deglycosylated. Canakinumab binds to human IL-1β and neutralizes its inflammatory activity by blocking its interaction with IL-1 receptors, but it does not bind IL-1alpha or IL-1 receptor antagonist (IL-1ra). 

References:

1. Church LD, McDermott MF: Canakinumab, a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders. Curr Opin Mol Ther. 2009 Feb;11(1):81-89.
 
2. Lachmann HJ, et al.: Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med. 2009 Jun 4;360(23):2416-25. doi:     10.1056/NEJMoa0810787
 
Purification : Purity: >98.0% as determined by SEC-HPLC & SDS-PAGE.
Content : 10mM Phosphate pH-7.0, 150 mM NaCl, 20% Glycerol
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Amino acid sequence : PepMap Analysis of N terminal amino acids sequence : H chain: QVQLVESGGG, L chain: EIVLTQSPDFQS

Specificity: Human IL1 beta. Does not cross react with other members of the interleukin-1 family. 

Inquire for more than 1 mg quantities.
 
Availability 5-7 weeks.
 

 


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Recombinant anti-human-IL-1β Antibody (Canakinumab)

Product code: 10-2003
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