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| Alternative Name : |
Angiopoietin-related protein 2, Angiopoietin-like protein 2, ANGPTL2, ARP2, HARP. |
| Amount : |
10 µg |
Source : Escherichia Coli.
ANGPTL2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 481 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 56kDa (calculated).
Angiopoietins belong to the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietins-1, 2 and 4 partake in the formation of blood vessels. ANGPTL2 displays angiogenic effects. Angiopoietin-like Protein 2 (ANGPTL2) is an anti-diabetic factor. ANGPTL2 induces sprouting in endothelial cells through an autocrine and paracrine action. ANGPTL2 increases insulin sensitivity in adipocytes. In addition, ANGPTL2 is a mediator of chronic adipose tissue inflammation. ANGPTL2 is widely expressed in the heart, small intestine, spleen and stomach. ANGPTL2 is also found in lower levels in the colon, ovary, adrenal gland, skeletal muscle and in prostate.
It is recommended to add 0.1M Acetate buffer pH-4 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, an intensive dilution by relevant buffer to a concentration of 10µg/ml is recommended. In higher concentrations the solubility of the ANGPTL2 is limited. ANGPTL2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
