|
|
| Gene : |
KDM8 |
| Gene ID : |
79831 |
| Uniprot ID : |
Q8N371 |
| Alternative Name : |
KDM8, JMJD5 |
| Format : |
Purified |
| Amount : |
100 µg |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
A partial length recombinant JMJD5 protein (amino acids 20-220) was used as the immunogen for this antibody. |
JMJD5 (Jumonji domain-containing protein 5) or commonly called as Lysine-specific demethylase 8 is a histone lysine demethylase that specifically demethylates dimethylated Lys 36 of histone H3 (H3K36me2) thereby activating the target gene. JMJD5 is important for G2/M phase cell cycle progression. JMJD5 is also a potential tumor suppression protein. JMJD5 helps in regulation of cancer proliferation by regulating cyclin-A1. JMJD5 has three isoforms (47, 24, 50 kDa), all localized in nucleus. JMJD5 is weakly expressed in most normal cells but highly expressed in breast cancer cells.
Western blot analysis: 2-4 µg/ml
