|
|
| Gene : |
COTL1 |
| Gene ID : |
23406 |
| Uniprot ID : |
Q14019 |
| Alternative Name : |
Coactosin-like protein, COTL1, CLP, FLJ43657, MGC19733. |
| Format : |
Purified |
| Amount : |
20 µg |
| Clone name : |
PAT1D6ATe |
| Isotype : |
Mouse IgG2b heavy chain and k light chain. |
| Immunogen Information : |
Anti-human COTL1 mAb,
clone PAT1D6AT, is derived from hybridization of mouse F0 myeloma cells with
spleen cells from BALB/c mice immunized with a recombinant human COTL1 protein 1-142
amino acids purified from E. coli. |
Coactosin-like protein (COTL1) is one of the numerous actin-binding proteins which regulate the actin cytoskeleton. COTL1 binds F-actin, it also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. COTL1 binds to F-actin in a calcium-independent way and has no direct effect on actin depolymerization.
The antibody has been tested by ELISA, Western blot
analysis to assure specificity and reactivity. Since application varies,
however, each investigation should be titrated by the reagent to obtain optimal
results. Recommended starting dilution is 1:1000.
