|
|
| Gene : |
OTUD5 |
| Gene ID : |
55593 |
| Uniprot ID : |
Q96G74 |
| Alternative Name : |
OTUD5 |
| Format : |
Purified |
| Amount : |
100 µg |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
A partial length recombinant DUBA protein (amino acids 300-520) was used as the immunogen for this antibody. |
DUBA belongs to a subfamily of 14 DUBs characterized by an OTU (Ovarian Tumor) domain. This protein suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. DUBA forms a direct complex with p53 and controls level of ubiquitination. The function of DUBA is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.
Western blot analysis: 2-4 µg/ml
