|
|
| Gene : |
CTLA4 |
| Gene ID : |
1493 |
| Uniprot ID : |
P16410 |
| Alternative Name : |
GSE, CD152, IDDM12, CELIAC3, CTLA-4. |
| Format : |
Purified |
| Amount : |
1 mg |
| Clone name : |
RYNmCTLA-4. |
| Isotype : |
Hamster IgG. |
| Immunogen Information : |
mixture of mouse activated T cells. |
CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
