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| Alternative Name : |
pro BDNF Antibody (5H8),BDNF |
| Amount : |
200 µg/ml |
| Clone name : |
5H8 |
| Isotype : |
IgG1 kappa light chain |
pro BDNF Antibody (5H8) is an IgG1 κ mouse monoclonal pro BDNF antibody (also designated preproprotein BDNF antibody) that detects the pro BDNF protein of mouse, rat, human, bovine, porcine and canine origin by WB, IP and IF. pro BDNF Antibody (5H8) is available as both the non-conjugated anti-pro BDNF antibody form, as well as multiple conjugated forms of anti-pro BDNF antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Neurotrophins function to regulate naturally occurring cell death of neurons during development. The prototype neurotrophin is nerve growth factor (NGF), originally discovered in the 1950s as a soluble peptide promoting the survival of, and neurite outgrowth from, sympathetic ganglia. Three additional structurally homologous neurotrophic factors have been identified. These include brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) (also designated NT-5). These various neurotrophins stimulate the in vitro survival of distinct, but partially overlapping, populations of neurons. The cell surface receptors through which neurotrophins mediate their activity have been identified. For instance, the Trk A receptor is the preferential receptor for NGF, but also binds NT-3 and NT-4. The Trk B receptor binds both BDNF and NT-4 equally well, and binds NT-3 to a lesser extent, while the Trk C receptor only binds NT-3.
