|
|
| Gene : |
BCL10 |
| Gene ID : |
8915 |
| Uniprot ID : |
O95999 |
| Alternative Name : |
BCL10, CIPER, CLAP |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
SPM520 |
| Isotype : |
Mouse IgG1, kappa |
| Immunogen Information : |
Human BCL10 recombinant protein (epitope aa122-168) |
BCL10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1;14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of BCL10 was shown to induce NF??B activation in a NIK-dependent pathway. This MAb labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1;14) translocation, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.
Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Western Blot (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);
