|
|
| Gene : |
DSG3 |
| Gene ID : |
1830 |
| Uniprot ID : |
P32926 |
| Alternative Name : |
DSG3, CDHF6 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM4A31 |
| Isotype : |
Mouse IgG2b Kappa |
| Immunogen Information : |
A partial length recombinant Desmoglein 3 protein (amino acids 328-526) was used as the immunogen for this antibody. |
DSG3 (Desmoglein 3) is a calcium-binding transmembrane glycoprotein component of desmosomes, conferring strong cell-cell adhesion. Desmosomes are button-like points of intercellular contact that allow the attachment of cytoskeletal elements to the plasma membrane at sites of cell-cell adhesion. DSG3 is expressed in basal and immediate suprabasal layers of skin. To maintain cell-cell adhesion DSG3 interacts with other desmosomal proteins, such as plakoglobin. Plakoglobin is closely related to Beta-catenin, which is a well-known downstream effector molecule in the canonical Wnt signaling pathway.DSG3 also promotes cancer cell growth and invasion through a plakoglobin-mediated signaling pathway.
Immunohistochemical analysis: 1 µg/ml
