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Gene : |
EGFR |
Gene ID : |
1956 |
Uniprot ID : |
P00533 |
Alternative Name : |
EGFR, ERBB, ERBB1, HER1 |
Amount : |
50 µg |
Isotype : |
Camelid VHH |
Alpaca derived anti-EGFR VHH single domain antibody (molecular weight:14.8 kDa) with a 6*His tag at its C-terminal, expressed in E. coli under conditions free from animal derived components.
EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. Growth factor receptors are involved not only in promoting the proliferation of normal cells but also in the aberrant growth of many types of human tumors. Over-expression of the EGFR gene occurs in carcinomas with and without gene amplification. EGFR and erbB-2 are particularly important in breast cancer because increased production or activation has been associated with poor prognosis. EGFR belongs to a family of growth factor receptors, which also includes ErbB-2/HER-2/neu, ErbB-3/HER-3/neu and ErbB-4/HER-4neu. EGFR can heterodimerize with each of the members of this family.
Specificity: Epidermal Growth Factor Receptor 1 (HER1/EGFR)
This is a product from Jotbody, Hong Kong. This antibody is made available by ABGENEX.
Positive controls: Positive IHC detected in: human lung carcinoma tissue Positive IF detected in: MCF-7 cells .
Recommended dilutions :Elisa 1:1000-1:25000 IHC 1:200-1:600 IF 1:200-1:600