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| Alternative Name : |
Cell Adhesion Molecule 1, Tumor Suppressor In Lung Cancer
1, IGSF4, Spermatogenic Immunoglobulin Superfamily, Immunoglobulin Superfamily,
Member 4, Immunoglobulin Superfamily Member 4, Synaptic Cell Adhesion Molecule,
Nectin-Like Protein 2, Nectin-Li |
| Amount : |
10 µg |
Source : Escherichia Coli.
CADM1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 353 amino acids (45-374 a.a) and having a molecular mass of 39.4 kDa.
CADM1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Cell Adhesion Molecule 1, also known as CADM1 belongs to the nectin family. CADM1 mediates homophilic cell-cell adhesion in a Ca2+-independent manner as well as mediating heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. Furthermore, CADM1 perform as a tumor suppressor in non-small-cell lung cancer, NSCLC, cells. The interaction with CRTAM promotes natural killer (NK) cell cytotoxicity & interferon-gamma secretion by CD8+ cells in vitro over and above NK
cell-mediated rejection of tumors expressing CADM3 in vivo.
