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| Alternative Name : |
Cyclin-Dependent Kinase 2, Cell Division Protein Kinase
2, P33 Protein Kinase, EC 2.7.11.22, CDKN2, Cdc2-Related Protein Kinase, P33(CDK2),
EC 2.7.11, Cyclin-dependent kinase 2. |
| Amount : |
10 µg |
Source : Sf9,
Baculovirus cells.
CDK2 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 306 amino acids (1-298a.a.) and having a molecular mass of 34.9kDa.
CDK2 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Cyclin-dependent kinase 2 (CDK2) belongs the Ser/Thr protein kinase family. CDK2 is highly parallel to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is limited to the G1-S phase, and is vital for cell cycle G1/S phase transition. The CDK2 protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). CDK2 activity is also regulated by protein phosphorylation.
