|
|
| Alternative Name : |
Cathepsin
E, EC 3.4.23.34, CATE, Erythrocyte Membrane Aspartic Proteinase, Slow-Moving
Proteinase, EC 3.4.23. |
| Amount : |
20 µg |
Source : Escherichia Coli.
CTSE Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 330 amino acids (57-363 a.a) and
having a molecular mass of 35.4kDa.CTSE is fused to a 23 amino acid His-tag at
N-terminus & purified by proprietary chromatographic techniques.
Cathepsin-E also known as CTSE is a gastric aspartyl protease which
functions as a disulfide-linked homodimer. CTSE belongs to the peptidase C1 family;
furthermore it has specificity similar to pepsin A and cathepsin D. CTSE is an
intracellular proteinase which does not seem to be involved in the digestion of
dietary protein and is found in the
uppermost concentration in the surface
of epithelial mucus-producing cells of the stomach. CTSE is the first aspartic proteinase expressed in the fetal stomach and is discovered in more
than half of gastric cancers. For that reason CTSE is an oncofetal
antigen. In addition, transcript variants utilizing alternative polyadenylation
signals and two transcript variants encoding different
isoforms exist for this gene.
