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| Alternative Name : |
Eukaryotic Translation Initiation Factor 3, Subunit I, EIF3S2,
Eukaryotic Translation Initiation Factor 3, Subunit 2 Beta, 36kDa, Eukaryotic
Translation Initiation Factor 3 Subunit 2, TRIP-1, eIF-3-beta, EIF3 P36, TGF-Beta
Receptor-Interacting Protei |
| Amount : |
20 µg |
Source : Escherichia Coli.
EIF3I Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 348 amino acids (1-325aa) and having a molecular mass of 38.9kDa.EIF3I is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Eukaryotic translation initiation factor 3, subunit I (EIF3I) is part of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is essential for numerous steps in the initiation of protein synthesis. The eIF-3 complex links with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2: GTP: methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also essential for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits
prior to initiation. Among the diseases associated with EIF3I are clonorchiasis, and tonsillitis.
