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| Alternative Name : |
Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide,
FCE1A, IgE Fc Receptor Subunit Alpha, FcERI, Fc-Epsilon RI-Alpha, Fc Epsilon RI
Alpha-Chain, Fc IgE Receptor, Alpha Polypeptide, High Affinity Immunoglobulin
Epsilon Receptor Alpha |
| Amount : |
20 µg |
Source : Escherichia Coli.
FCER1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 203 amino acids (26-205aa) and having a molecular mass of 23.4kDa.FCER1A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide (FCER1A) binds to the Fc region of immunoglobulins epsilon. FCER1A is a high affinity receptor. In addition FCER1A is responsible for starting the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators such as histamine which is responsible for the manifestations of allergy. This receptor is contains of an alpha subunit, a beta subunit, and two gamma subunits. FCER1A stands for the alpha subunit.
Among the diseases associated with FCER1A are mast-cell leukemia, and allergic
asthma.
