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| Alternative Name : |
Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide,
Guanine Nucleotide-Binding Protein Alpha-Q, CMC1, SWS, GAQ, Guanine
Nucleotide-Binding Protein G(Q) Subunit Alpha, G-ALPHA-Q, Guanine
nucleotide-binding protein G(q) subunit alpha. |
| Amount : |
20 µg |
Source : Escherichia Coli.
GNAQ Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 382 amino acids (1-359 a.a) and having a molecular mass of 44.5kDa.
GNAQ is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
GNAQ, also known as Guanine nucleotide-binding protein belong to the G-alpha family. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in a variety of transmembrane signaling systems. GNAQ regulates B-cell selection and survival and is essential in order to prevent B-cell-dependent autoimmunity. GNAQ also regulates chemotaxis of BM-derived neutrophils and dendritic cells, in vitro. GNAQ is an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been connected with problems in platelet activation and aggregation. A related pseudogene to GNAQ exists on chromosome 2.
