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| Alternative Name : |
Guanine nucleotide binding protein (G protein) beta polypeptide 2-like 1, RACK1, Receptor for Activated C Kinase 1, Gnb2-rs1, H12.3, Cell proliferation-inducing gene 21 protein, Guanine nucleotide-binding protein subunit beta-like protein 12.3, Human |
| Amount : |
10 µg |
Source : E.coli.
GNB2L1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 337 amino acids (1-317 and having a molecular mass of 37.2kDa.GNB2L1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
GNB2L1 was first known as an anchoring protein for protein kinase C beta (PKCbeta), which it stabilizes in the active state and anchors to membranes or functional sites. But, there is now confirmation that GNB2L1 has an essential part of in critical biological responses. GNB2L1 binds specifically to the active form of PKCbeta isoforms and cooperates with numerous other vital signaling proteins such as the androgen receptor, the Src kinase family, integrin beta1, integrin beta2, integrin beta3 and integrin beta5, beta-spectrin and dynamin, RasGAP, insulin-like growth factor 1 receptor (IGF-1r), Epstein-Barr virus trans-activator protein BZLF1, p73 and pRB. GNB2L1 is highly expressed in tissues of higher mammals and humans including spleen, liver and brain.
