|
|
| Alternative Name : |
H2A Histone Family, Member Z, H2AZ, H2A/z, H2A.Z-1, H2A.z,
H2AZ Histone, Histone H2A.Z. |
| Amount : |
10 µg |
Source : Escherichia Coli.
H2AFZ Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 151 amino acids (1-128 a.a) and
having a molecular mass of 15.9kDa.H2AFZ is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Histone
H2A.Z (H2AFZ) belongs to the histone H2A family. Histones are basic nuclear
proteins which are responsible for the nucleosome structure of the chromosomal
fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped
around a histone octamer composed of pairs of each of the four core histones
(H2A, H2B, H3, and H4). H2AFZ is implicated in the formation of constitutive
heterochromatin and vital for chromosome segregation during cell division.
Moreover, variant Histone H2A, which takes the place of conventional H2A in a
subset of nucleosomes. Studies in mice have demonstrated that this particular
histone is essential for embryonic development and show that lack of functional
histone H2A leads to embryonic lethality.
