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| Alternative Name : |
DRB1, HLA DRB1, HLA-DR1B, HLA-DRB1, MHC class II antigen
DRB1 16, DR-16, DR16, Human Leucocyte AntigenDRB1, MHC Class
IIHLA-DR-Beta Cell Surface Glycoprotein, MHC Class IIHLA-DRw10-Beta. |
| Amount : |
20 µg |
Source : Escherichia Coli.
HLA-DRB1 Human Recombinant produced in E.Coli is a
single, non-glycosylated polypeptide chain containing 219 amino acids (30-227 a.a)
and having a molecular mass of 25.2kDa.HLA-DRB1 is fused to a 21 amino acid His-tag at
N-terminus & purified by proprietary chromatographic techniques.
Major Histocompatibility Complex Class II DR Beta 1 also known as HLA-DRB1 ia a member of the HLA class II beta chain paralogs. Molecule class II is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. HLA-DRB1 takes an essential part in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Furthermore, the beta chain is approximately 26- 28 kDa. It is encoded by 6 exons. While exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail.
