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| Alternative Name : |
High Mobility Group AT-Hook 2, HMGIC, High-Mobility Group
(Nonhistone Chromosomal) Protein Isoform I-C, High Mobility Group AT-Hook
Protein, BABL, HMGI-C, LIPO, STQTL9, High Mobility Group Protein HMGI-C,
HMGA2. |
| Amount : |
10 µg |
Source : Escherichia Coli.
HMGA2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 117 amino acids (1-109 a.a) and having a molecular mass of 12.8kDa.HMGA2 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
High Mobility Group AT-Hook 2 (HMGA2) is a member
of the non-histone chromosomal high mobility group (HMG) family. HMG proteins perform
as architectural factors and are necessary components of the enhancesome. This protein contains
structural DNA-binding domains and may function as a transcriptional regulating
factor. In addition, identification of the deletion, amplification, and rearrangement of this
gene that are associated with myxoid liposarcoma proposes a role in adipogenesis and mesenchymal differentiation.
A gene knock out study of the mouse counterpart demonstrated that this gene is implicated
in diet-induced obesity. Among
the Diseases associated with HMGA2 are diffuse lipomatosis, and 12q14
microdeletion syndrome.
