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| Alternative Name : |
Homeobox A9, HOX1G, Homeobox Protein Hox-1G, Homeodomain Protein HOXA9, Homeobox Protein Hox-A9, Homeo Box A9, HOX1.7, ABD-B, HOX1, HOXA9. |
| Amount : |
20 µg |
Source : Escherichia Coli.
HOXA9 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 295 amino acids (1-272) and having a molecular mass of 32.6 kDa.HOXA9 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Homeobox A9 (HOXA9) is a member of the Abd-B homeobox family. The HOXA9 protein is a transcription factor with a key role in both haemopoiesis and leukaemia. High levels of HOXA9 expression in haemopoietic cells is a distinctive feature of acute myeloid leukaemia (AML), and may be sufficient to cause this disease. HOXA9 overexpression noticeably expands hematopoietic stem cells. The HOXA9 gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which regulates gene expression, morphogenesis, and differentiation. HOXA9 is a sequence-specific transcription factor which is part of a developmental regulatory system, which provides cells with specific positional identities on the anterior-posterior axis. HOXA9 is essential for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.
