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| Alternative Name : |
immediate early response 3, DIF-2, DIF2, GLY96, IEX-1,
IEX-1L, IEX1, PRG1, Protein DIF-2, Immediate early protein GLY96, PACAP-responsive gene 1
protein, Differentiation-dependent gene 2 protein, IER3. |
| Amount : |
10 µg |
Source : Escherichia Coli.
IER3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 105 amino acids (1-82 a.a.) and having a molecular mass of 11.4kDa.IER3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Immediate Early Response 3 (IER3) functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. IER3 has a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. In addition, IER3 serves as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, IER3 provides pancreatic ductal adenocarcinoma with significant resistance to cell stress, such as starvation or gemcitabine treatment.
