|
|
| Alternative Name : |
Interferon Gamma-Inducible Protein 30, Gamma-Interferon-Inducible Lysosomal Thiol Reductase, Interferon Gamma-Inducible Protein 30 Preproprotein, Gamma-Interferon-Inducible Protein IP-30, Legumaturain, GILT, IP30, IFI-30, MGC32056, EC 1.8. |
| Amount : |
10 µg |
Source : E.coli. IFI30 Human Recombinant produced in E. coli is a single polypeptide chain containing 199 amino acids (58-232) and having a molecular mass of 22.5 kDa. IFI30 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. gamma-interferon-inducible lysosomal thiol reductase (IFI30), is a part of the GILT family. IFI30 is a lysosomal thiol reductase which at low pH is capable of decreasing protein's disulfide bonds. IFI30 is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. Also, IFI30 plays an important role in MHC class II-restricted antigen processing. IFI30 facilitates the generation of MHC class II-restricted epitopes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds and Also facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or cross-presentation.
