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Alternative Name : |
CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8. |
Amount : |
10 µg |
Source : HEK.
IL-17 Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight range of 30-35kDa due to glycosylation.The IL-17 is purified by proprietary chromatographic techniques.
IL17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
It is recommended to reconstitute the lyophilized IL-17 in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions. The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF Adult fibroblasts and is typically 5-25ng/ml.