|
|
| Alternative Name : |
T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2. |
| Amount : |
10 µg |
Source : HEK.
Interleukin-2 Human Recombinant produced in HEK cells is a glycosylated monomer, having a total molecular weight of 15kDa.The IL2 is purified by proprietary chromatographic techniques.
IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
It is recommended to reconstitute the lyophilized IL-2 in sterile PBS containing 0.1% endotoxin-free recombinant HSA. The specific activity was determined by the dose-dependent stimulation of the proliferation of mouse CTLL-2 cells (mouse cytotoxic T cell line) and is typically 0.2-2ng/ml.
