|
|
| Alternative Name : |
Lysyl Oxidase, EC 1.4.3.13, Protein-lysine 6-oxidase, Lysyl
oxidase. |
| Amount : |
20 µg |
Source : E.coli.
LOX Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 272 amino acids (169-417a.a) and
having a molecular mass of 31.4kDa.LOX is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Lysyl Oxidase also known as LOX
is an extracellular copper enzyme which initiates the crosslinking of
collagens and elastin. LOX catalyzes
oxidative deamination of the epsilon-amino group in certain lysine and
hydroxylysine residues of collagens and lysine residues of elastin. Adding up
to crosslinking extracellular matrix proteins, LOX plays a part in tumor
suppression. Moreover, defects in LOX are the cause of autosomal recessive
cutis laxa type I, CL type I. Two transcript variants encoding dissimilar isoforms
have been found for LOX.
