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Gene : |
TNFAIP3 |
Gene ID : |
7128 |
Uniprot ID : |
P21580 |
Alternative Name : |
TNFAIP3, OTUD7C |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
ABM1G20 |
Isotype : |
Mouse IgG1 Kappa |
Immunogen Information : |
A partial length recombinant protein from C terminal portion of A20 was used as the immunogen for this antibody. |
A20 (also known as TNFAIP3) is a potent anti-inflammatory signaling molecule that restricts multiple intracellular signaling cascades. It is a pleiotropically expressed cytoplasmic protein, the expression of which is regulated at both the transcriptional and the post-transcriptional level. In most cell types, A20 is rapidly induced by NF-KappaB in a negative feedback loop that maintains a transient NF-KappaB response. In addition, post-translational modifications of A20 — including phosphorylation, protein cleavage, glycosylation and ubiquitylation — may serve to support or restrict its activity. A20 targets the E3 ubiquitin ligase TRAF6 in the TLR4/IL-1R pathway by antagonizing interactions with the E2 enzymes Ubc13 and UbcH5c. A20 also promotes cell-survival signals, adding another dimension to its ability to regulate dynamic immune responses.
Western blot analysis: 4-6 µg/ml