|
|
| Gene : |
BCL6 |
| Gene ID : |
604 |
| Uniprot ID : |
P41182 |
| Alternative Name : |
BCL6, BCL5, LAZ3, ZBTB27, ZNF51 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM44G9 |
| Isotype : |
Mouse IgG2b Kappa |
| Immunogen Information : |
A partial length recombinant BCL-6 protein (amino acids 200-401) was used as the immunogen for this antibody. |
BCL6 (B-cell lymphoma 6) is a 95 kDa zinc finger transcription factor and contains an N-terminal POZ domain. BCL6 is a transcriptional repressor and a master regulator of the germinal center (GC) B cell phenotype controlling its development and growth. BCL-6 modulates IL-4, BCR, and CD40L signals for normal B cell development. Altered BCL6 protein expression is implicated in pathogenesis of diverse human hematologic malignancies, especially in the diffuse large B cell lymphoma (DLBCL), the most common lymphoma in adults. BCL6 suppresses the expression of p53 (also known as tp53) tumor suppressor gene and modulates DNA damage-induced apoptotic responses in GC B cells.
Western blot analysis: 2-4 µg/ml
