|
|
| Gene : |
ERBB2 |
| Gene ID : |
2064 |
| Uniprot ID : |
P04626 |
| Alternative Name : |
ERBB2, HER2, MLN19, NEU, NGL |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM45F5 |
| Isotype : |
Mouse IgG2b Kappa |
| Immunogen Information : |
A partial length protein (amino acids 301-522) was used as the immunogen for this antibody (from extra cellular domain of c-erbB-2). |
HER2, a known proto-oncogene, is located at the long arm of human chromosome 17 (17q12), encoding a type 1 tyrosine kinase growth factor receptor and the role of HER2 in the development of numerous types of human cancer. HER2 is a transmembrane receptor comprising an extracellular domain (ECD), a single transmembrane domain, and an intracellular domain (ICD) with tyrosine-kinase activity.The high-expression and amplification of C-erbB-2 and its protein products (P185) are found in a wide variety of tumors. HER2 is overexpressed in 10% to 35% of gastric and gastroesophageal junction (GEJ) adenocarcinomas.
Immunohistochemical analysis: 5-10 µg/ml
