|
|
| Gene : |
SEMA4D |
| Gene ID : |
10507 |
| Uniprot ID : |
Q92854 |
| Alternative Name : |
SEMA4D, C9orf164, CD100, SEMAJ |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
A8 |
| Isotype : |
Mouse IgG1, kappa |
| Immunogen Information : |
PHA stimulated human peripheral blood lymphocytes |
Recognizes a homodimeric protein comprised of 50kDa subunits, identified as CD100. It is expressed on majority of haemopoietic cells (B, T, NK and myeloid cells) and is absent from bone marrow, erythrocytes, eosinophils and endothelial cells. Its expression is increased after PHA-activation. CD100 was shown to associate with different partner molecules in T cells such as CD45, a key molecule with protein tyrosine phosphatase activity involved in T-cell transduction, and a Serine kinase. It plays a role in homotypic cell adhesion and in T cell activation.
Functional Studies (Order Ab without Azide);Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml);
