|
|
| Gene : |
ITGAX |
| Gene ID : |
3687 |
| Uniprot ID : |
P20702 |
| Alternative Name : |
ITGAX, CD11C |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM4C58 |
| Isotype : |
Mouse IgG2b Kappa |
| Immunogen Information : |
A partial length recombinant CD11c protein (amino acids 620-835) was used as the immunogen for this antibody. |
CD11c/CD18 (?X?2, p150/95, or complement receptor 4, CR4) is a monocyte/macrophage-enriched integrin that has been reported to bind to a variety of ligands. These include cell surface proteins (LPS, ICAM-1, ICAM-2, ICAM-4 and VCAM-1), extracellular matrix proteins (collagen I), and soluble ligands (iC3b, heparin and fibrinogen). It is expressed in macrophages, monocytes, granulocytes, subsets of T and B cells, and dendritic cells. CD11c functions as a cell surface receptor for numerous soluble factors and proteins. The interaction mediates leukocyte interactions with other cell types and is a signal transducing receptor. It is found primarily on myeloid cells, where its expression is regulated both during differentiation and during monocyte maturation into tissue macrophages.
Immunohistochemical analysis: 5-10 µg/ml
FACS: 0.5 - 1 µg/10^6 cells
