|
|
| Gene : |
KLRB1 |
| Gene ID : |
3820 |
| Uniprot ID : |
Q12918 |
| Alternative Name : |
Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, NKR-P1A, Natural killer cell surface protein P1A, CD161 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM27F5 |
| Isotype : |
Mouse IgG2b, Kappa |
| Immunogen Information : |
Full length recombinant protein of hCD161 was used as the immunogen for this antibody. |
CD161 is the human equivalent of mouse NK cell receptor P1A. It is a type II transmembrane glycoprotein with characteristics of the C-type lectin superfamily. The expression confines to lymphocytes found in human gut and liver, as well as blood, especially NK (natural killer) cells, Th17 (T helper 17) cells, and a population of unconventional T cells known as MAIT (mucosal-associated invariant T) cells. CD161 promotes T cell expansion and eventually has been identified as a marker of human IL-17-producing T cells. It plays a pivotal role in trans-endothelial migration and is also implicated in the pathogenesis of RA (rheumatoid arthritis) as well as graft-versus-host disease (GVHD).
FACS analysis: 0.5-1 µg/10^6 cells
