|
|
| Gene : |
CD19 |
| Gene ID : |
930 |
| Uniprot ID : |
P15391 |
| Alternative Name : |
CD19 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
CVID3/429 |
| Isotype : |
Mouse IgG1, kappa |
| Immunogen Information : |
Recombinant human CD19 protein |
CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is present in both benign and malignant B-cells and is considered to be the most reliable surface marker of this lineage over a wide range of maturational stages. In normal lymphoid tissue, CD19 is observed in germinal centers, in mantle zone cells, and in scattered cells of the inter-follicular areas. Anti-CD19 exhibits an overall immunoreactivity pattern similar to those of the antibodies against CD20 and CD22. However, in contrast to CD20, expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. Anti-CD19 positivity is seen in the vast majority of B-cell neoplasms commonly at a lower intensity than normal B-cell counterparts. Plasma cell neoplasms are nearly always negative, as are T-cell neoplasms.
Flow Cytometry (1-2ug/million cells); ,Immunofluorescence (1-2ug/ml); ,
