|
|
| Gene : |
CD22 |
| Gene ID : |
933 |
| Uniprot ID : |
P20273 |
| Alternative Name : |
CD22, SIGLEC2 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
FR10B4 |
| Isotype : |
Mouse IgG1, kappa |
| Immunogen Information : |
Human BurkittÂ’s lymphoma cells |
Recognizes a protein of 130-140kDa, identified as CD22 (also known as BL-CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.
Functional Studies (Order Ab without Azide); Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml);
