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|
Gene : |
DPP4 |
Gene ID : |
1803 |
Uniprot ID : |
P27487 |
Alternative Name : |
DPP4, ADCP2, CD26 |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
202.36 |
Isotype : |
Mouse IgG2b, kappa |
Immunogen Information : |
Human T cell clone |
Recognizes a glycoprotein of 110kDa, identified as CD26 (Workshop VI; Code: N-L039). It is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Cross-linking of CD26 using this antibody dramatically enhances the anti-CD3-induced IL-2 production. In Western blotting, this MAb reacts with only glycosylated CD26, but not with the deglycosylated form. It does not prevent ADA binding to CD26.
Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Immunohistochemistry (Frozen Only) (1-2ug/ml for 30 minutes at RT)