|
|
| Gene : |
CD33 |
| Gene ID : |
945 |
| Uniprot ID : |
P20138 |
| Alternative Name : |
CD33, SIGLEC3 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM29D3 |
| Isotype : |
Mouse IgG2a Kappa |
| Immunogen Information : |
A partial length recombinant CD33 protein (amino acids 28-320) was used as the immunogen for this antibody. |
CD33 is a member of the SIGLEC (Sialic Acid-Binding Ig-Like Lectin) family of receptors, and the gene comprises seven coding exons. Exon 2 encodes the canonical IgV domain, exon 4 encodes the IgC structural domain, and exons 6 and 7 encode cytosolic ITIMs (Immunotyrosine Inhibitory Motifs). CD33 acts as a cell surface antigen which is expressed on normal myeloid cells and CD34+ blasts in AML (Acute Myeloid Leukemia). The antigen serves as a target of GO (Gemtuzumab/Ozogamicin), which exerts anti-leukemic effects in refractory AML.
Western blot analysis: 2-4 µg/ml,
Immunohistochemical analysis: 5 µg/ml
FACS: 0.2-0.5 µg/10^6 cells
