|
|
| Gene : |
CD34 |
| Gene ID : |
947 |
| Uniprot ID : |
P28906 |
| Alternative Name : |
CD34 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ICO-115 |
| Isotype : |
Mouse IgG1, kappa |
| Immunogen Information : |
Blast cells from a chronic myeloid leukemia patient were used as the immunogen for the CD34 antibody. |
CD34 a type 1 transmembrane protein, belonging to the sialomucin family, has important roles in adhesion which remain to be fully elucidated. CD34 has an intracellular cytoplasmic domain containing consensus sites for serine, theronine, tryrosine and active protein kinase C (PKC) phosphorylation thereby implicating a role for the protein in signal transduction processes. CD34 expression, as identified by antibody, is a hallmark for identifying pluripotential hematopoietic stem or progenitor cells. CD34 antibody positive populations expand and differentiate into the various lymphohematopoietic lineages. During differentiation, lineages lose CD34 expression and become CD34 antibody negative.
Immunohistochemistry (Formalin-fixed) (0.1-0.2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
