|
|
| Gene : |
CD36 |
| Gene ID : |
948 |
| Uniprot ID : |
P16671 |
| Alternative Name : |
CD36, GP3B, GP4 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
1A7 |
| Isotype : |
Mouse IgG2b, kappa |
| Immunogen Information : |
Human CD36 from platelets |
Recognizes a protein of 80kDa-90kDa, identified as CD36. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36.
Functional Studies (Order Ab without Azide);Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml);
