|
|
| Gene : |
CD46 |
| Gene ID : |
4179 |
| Uniprot ID : |
P15529 |
| Alternative Name : |
CD46, MCP, MIC10 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
122.2 |
| Isotype : |
Mouse IgG1, kappa |
| Immunogen Information : |
Recombinant human CD46 protein |
CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Functional Studies (Order Ab without Azide);Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml);
