|
|
| Gene : |
CD53 |
| Gene ID : |
963 |
| Uniprot ID : |
P19397 |
| Alternative Name : |
CD53, MOX44, TSPAN25 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
63-5A3 |
| Isotype : |
Mouse IgG2b, kappa |
| Immunogen Information : |
Human Sezary cells |
Recognizes a protein of 33-55kDa, identified as CD53 (Workshop V; Code CD53.1). CD53 is expressed on monocytes, and macrophages, granulocytes, dendritic cells, osteoblasts and osteoclasts, NK cells, and on T- and B-cells from every stage of differentiation but is absent from platelets, erythrocytes, and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins, including CD9, CD37, CD63, CD81, and CD82. It associates with integrins, MHC class II molecules, and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells, monocytes, and granulocytes and activation of the monocyte oxidative burst.
Functional Studies (Order Ab without Azide);Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml);
