|
|
| Gene : |
CD63 |
| Gene ID : |
967 |
| Uniprot ID : |
P08962 |
| Alternative Name : |
CD63, MLA1, TSPAN30 |
| Format : |
Purified |
| Amount : |
0.5 ml |
| Clone name : |
SPM524 |
| Isotype : |
Mouse IgG1, kappa |
| Immunogen Information : |
Smooth plasma membrane fraction of MeWo cells |
The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood);Immunofluorescence (1:50-1:100);
