|
|
| Gene : |
NT5E |
| Gene ID : |
4907 |
| Uniprot ID : |
P21589 |
| Alternative Name : |
NT5E, NT5, NTE |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM4F11 |
| Isotype : |
Mouse IgG2a Kappa |
| Immunogen Information : |
A partial length recombinant CD73 protein (amino acids 145-346) was used as the immunogen for this antibody. |
CD73, also known as ecto-5'-nucleotidase, is a glycosyl-phosphatidylinositol linked plasma membrane glycoprotein that is expressed on multiple cell types and in different tissues. It is a key enzyme in the regulation of purinergic signaling and inflammatory reactions. It hydrolyzes extracellular AMP into adenosine, which dampens immune cell activation, and reduces leukocyte trafficking CD73 potently suppresses antitumor T cell responses through its ability to generate adenosine. It has also emerged as an important regulator of tissue homeostasis and pathophysiologic responses related to immunity, inflammation, pain, ischemia, tissue fibrosis and cancer.
Western blot analysis: 2-4 µg/ml, FACS analysis: 0.5-1 µg/10^6 cells
