|
|
| Gene : |
CD8B |
| Gene ID : |
926 |
| Uniprot ID : |
P10966 |
| Alternative Name : |
CD8B, CD8B1 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
BU88 |
| Isotype : |
Mouse IgG1, kappa |
| Immunogen Information : |
Human CD8 beta |
The T cell receptor (TCR) is a heterodimer composed of either ? ? and ? ? or ? ? and ? ? chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8. T helper cells express CD4 proteins and T cytotoxic cells display CD8. CD8 (also designated Leu 2 or T8), a cell surface glycoprotein, is a two chain complex (? ?-? ? or ? ?-? ?) receptor that binds class I MHC molecules presented by the antigen-presenting cell (APC). A primary function of CD8 is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cells may be to maintain low levels of HIV expression.
ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA); Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml);
